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Prof. Marina Lynch
Trinity College Dublin
Research Interests: My research focuses on investigating the contribution of neuroinflammatory changes in the age-related and amyloid β-induced deterioration in synaptic function in the brain, especially in the hippocampus. A key component of neuroinflammation is activation of microglia and astrocytes and therefore a particular objective is to understand the factors which trigger activation of these cells, with the aim of modulating these changes and restoring synaptic function. Current work includes an evaluation of the role of cell-cell interaction in modulating microglial activation with a special focus on assessing the interaction between CD200 and its receptor. Among the factors which upregulates CD200 expression is the anti-inflammatory cytokine, IL-4 and recent studies have provided evidence that some novel anti-inflammatory agents attenuate age- and amyloid β-induced changes in hippocampus because they exert an effect on IL-4 and CD200 expression. My current research group consists of 6 postdoctoral fellows and 9 PhD students.